Curcuma Longa Therapy for the Management and Treatment of Type 2 Diabetes: Quasi Experimental Pilot Study Design
Keywords:
diabetes, type 2 diabetes, turmeric, curcumin, nutrition, nutrition intervention
Abstract
Background: Diabetes mellitus is a chronic metabolic condition defined by consistent hyperglycemia. By 2017, about 462 million individuals worldwide between the ages of 15 and 79 had type 2 diabetes mellitus (T2D). This global public health burden is expected to increase by 200 million by 2040. Curcumin, which is considered the active ingredient in turmeric, has been extensively researched concerning T2D. However, this pilot study will evaluate the efficacy of daily intake of turmeric root powder as a food agent in the management and treatment of T2D.
Method: This is a quantitative quasi-experimental pilot study design, with the primary objective to answer the following question: Can daily intake of turmeric root powder instead of curcumin effectively control blood glucose in persons with T2D?
Conclusion: This study aligns with principles and practices of complementary and integrative health we aim to show the efficacity and effectiveness of whole food agents as a nutritional intervention in the management and treatment of medical conditions such as T2D.
References
Al-Lawati, J. A. (2017). Diabetes Mellitus: A Local and Global Public Health Emergency! Oman Medical Journal, 32(3), 177–179. https://doi.org/10.5001/omj.2017.34
Asadi, S., Gholami, M. S., Siassi, F., Qorbani, M., & Sotoudeh, G. (2020). Beneficial effects of nano‐curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double‐blind, placebo‐controlled clinical trial. Phytotherapy Research, 34(4), 896-903. https://doi.org/10.1002/ptr.6571.
Asadi, S., Gholami, M. S., Siassi, F., Qorbani, M., Khamoshian, K., & Sotoudeh, G. (2019). Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial. Complementary Therapies in Medicine, 43, 253-260. https://doi.org/10.1016/j.ctim.2019.02.014.
Blaslov, K., Naranđa, F. S., Kruljac, I., & Renar, I. P. (2018). Treatment approach to type 2 diabetes: Past, present and future. World Journal of Diabetes, 9(12), 209–219. https://doi.org/10.4239/wjd.v9.i12.209
Bragg, F., Holmes, M. V., Iona, A., Guo, Y., Du, H., Chen, Y., Bian, Z., Yang, L., Herrington, W., Bennett, D., Turnbull, I., Liu, Y., Feng, S., Chen, J., Clarke, R., Collins, R., Peto, R., Li, L., Chen, Z., & China Kadoorie Biobank Collaborative Group. (2017). Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China. JAMA, 317(3), 280–289. https://doi.org/10.1001/jama.2016.19720
Chen, H., Chen, G., Zheng, X., & Guo, Y. (2019). Contribution of specific diseases and injuries to changes in health adjusted life expectancy in 187 countries from 1990 to 2013: Retrospective observational study. BMJ (Clinical Research Ed.), 364, l969. https://doi.org/10.1136/bmj.l969
Eknoyan, G., & Nagy, J. (2005). A history of diabetes mellitus or how a disease of the kidneys evolved into a kidney disease. Advances in Chronic Kidney Disease, 12(2), 223–229. https://doi.org/10.1053/j.ackd.2005.01.002
Goyal, R., & Jialal, I. (2020). Diabetes Mellitus Type 2. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK513253/
Guthrie, D. W., & Humphreys, Selbys. (1988). Diabetes Urine Testing: An Historical Perspective. The Diabetes Educator, 14(6), 521–525. https://doi.org/10.1177/014572178801400615
IDF Diabetes Atlas (10th ed.). (n.d.). Retrieved February 3, 2022, from https://diabetesatlas.org/
Introduction: Standards of Medical Care in Diabetes—2018. (2017). Diabetes Care, 41(Supplement_1), S1–S2. https://doi.org/10.2337/dc18-Sint01
Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). Dose escalation of a curcuminoid formulation. BMC Complementary and Alternative Medicine, 6, 10. https://doi.org/10.1186/1472-6882-6-10
Policardo, L., Seghieri, G., Anichini, R., De Bellis, A., Franconi, F., Francesconi, P., Del Prato, S., & Mannucci, E. (2015). Effect of diabetes on hospitalization for ischemic stroke and related in-hospital mortality: A study in Tuscany, Italy, over years 2004-2011. Diabetes/Metabolism Research and Reviews, 31(3), 280–286. https://doi.org/10.1002/dmrr.2607
Poolsup, N., Suksomboon, N., Kurnianta, P. D. M., & Deawjaroen, K. (2019). Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: a systematic review and meta-analysis. PloS One, 14(4), e0215840. https://doi.org/10.1371/journal.pone.0215840
Reece, E. A., & Homko, C. J. (1998). Diabetes mellitus in pregnancy. What are the best treatment options. Drug Safety, 18(3), 209–220. https://doi.org/10.2165/00002018
Rodbard, H. W., Blonde, L., Braithwaite, S. S., Brett, E. M., Cobin, R. H., Handelsman, Y., Hellman, R., Jellinger, P. S., Jovanovic, L. G., Levy, P., Mechanick, J. I., Zangeneh, F., & AACE Diabetes Mellitus Clinical Practice Guidelines Task Force. (2007). American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 13(Suppl 1), 1–68. https://doi.org/10.4158/EP.13.S1.1199818030-00005
Yang, J. J., Yu, D., Wen, W., Saito, E., Rahman, S., Shu, X.-O., Chen, Y., Gupta, P. C., Gu, D., Tsugane, S., Xiang, Y.-B., Gao, Y.-T., Yuan, J.-M., Tamakoshi, A., Irie, F., Sadakane, A., Tomata, Y., Kanemura, S., Tsuji, I., … Zheng, W. (2019). Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants. JAMA Network Open, 2(4), e192696. https://doi.org/10.1001/jamanetworkopen.2019.2696
Zheng, J., Cheng, J., Zheng, S., Feng, Q., & Xiao, X. (2018). Curcumin, A Polyphenolic Curcuminoid with Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy. Front Pharmacol., 9, 472. https://doi.org/10.3389/fphar.2018.00472
Asadi, S., Gholami, M. S., Siassi, F., Qorbani, M., & Sotoudeh, G. (2020). Beneficial effects of nano‐curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double‐blind, placebo‐controlled clinical trial. Phytotherapy Research, 34(4), 896-903. https://doi.org/10.1002/ptr.6571.
Asadi, S., Gholami, M. S., Siassi, F., Qorbani, M., Khamoshian, K., & Sotoudeh, G. (2019). Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial. Complementary Therapies in Medicine, 43, 253-260. https://doi.org/10.1016/j.ctim.2019.02.014.
Blaslov, K., Naranđa, F. S., Kruljac, I., & Renar, I. P. (2018). Treatment approach to type 2 diabetes: Past, present and future. World Journal of Diabetes, 9(12), 209–219. https://doi.org/10.4239/wjd.v9.i12.209
Bragg, F., Holmes, M. V., Iona, A., Guo, Y., Du, H., Chen, Y., Bian, Z., Yang, L., Herrington, W., Bennett, D., Turnbull, I., Liu, Y., Feng, S., Chen, J., Clarke, R., Collins, R., Peto, R., Li, L., Chen, Z., & China Kadoorie Biobank Collaborative Group. (2017). Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China. JAMA, 317(3), 280–289. https://doi.org/10.1001/jama.2016.19720
Chen, H., Chen, G., Zheng, X., & Guo, Y. (2019). Contribution of specific diseases and injuries to changes in health adjusted life expectancy in 187 countries from 1990 to 2013: Retrospective observational study. BMJ (Clinical Research Ed.), 364, l969. https://doi.org/10.1136/bmj.l969
Eknoyan, G., & Nagy, J. (2005). A history of diabetes mellitus or how a disease of the kidneys evolved into a kidney disease. Advances in Chronic Kidney Disease, 12(2), 223–229. https://doi.org/10.1053/j.ackd.2005.01.002
Goyal, R., & Jialal, I. (2020). Diabetes Mellitus Type 2. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK513253/
Guthrie, D. W., & Humphreys, Selbys. (1988). Diabetes Urine Testing: An Historical Perspective. The Diabetes Educator, 14(6), 521–525. https://doi.org/10.1177/014572178801400615
IDF Diabetes Atlas (10th ed.). (n.d.). Retrieved February 3, 2022, from https://diabetesatlas.org/
Introduction: Standards of Medical Care in Diabetes—2018. (2017). Diabetes Care, 41(Supplement_1), S1–S2. https://doi.org/10.2337/dc18-Sint01
Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). Dose escalation of a curcuminoid formulation. BMC Complementary and Alternative Medicine, 6, 10. https://doi.org/10.1186/1472-6882-6-10
Policardo, L., Seghieri, G., Anichini, R., De Bellis, A., Franconi, F., Francesconi, P., Del Prato, S., & Mannucci, E. (2015). Effect of diabetes on hospitalization for ischemic stroke and related in-hospital mortality: A study in Tuscany, Italy, over years 2004-2011. Diabetes/Metabolism Research and Reviews, 31(3), 280–286. https://doi.org/10.1002/dmrr.2607
Poolsup, N., Suksomboon, N., Kurnianta, P. D. M., & Deawjaroen, K. (2019). Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: a systematic review and meta-analysis. PloS One, 14(4), e0215840. https://doi.org/10.1371/journal.pone.0215840
Reece, E. A., & Homko, C. J. (1998). Diabetes mellitus in pregnancy. What are the best treatment options. Drug Safety, 18(3), 209–220. https://doi.org/10.2165/00002018
Rodbard, H. W., Blonde, L., Braithwaite, S. S., Brett, E. M., Cobin, R. H., Handelsman, Y., Hellman, R., Jellinger, P. S., Jovanovic, L. G., Levy, P., Mechanick, J. I., Zangeneh, F., & AACE Diabetes Mellitus Clinical Practice Guidelines Task Force. (2007). American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 13(Suppl 1), 1–68. https://doi.org/10.4158/EP.13.S1.1199818030-00005
Yang, J. J., Yu, D., Wen, W., Saito, E., Rahman, S., Shu, X.-O., Chen, Y., Gupta, P. C., Gu, D., Tsugane, S., Xiang, Y.-B., Gao, Y.-T., Yuan, J.-M., Tamakoshi, A., Irie, F., Sadakane, A., Tomata, Y., Kanemura, S., Tsuji, I., … Zheng, W. (2019). Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants. JAMA Network Open, 2(4), e192696. https://doi.org/10.1001/jamanetworkopen.2019.2696
Zheng, J., Cheng, J., Zheng, S., Feng, Q., & Xiao, X. (2018). Curcumin, A Polyphenolic Curcuminoid with Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy. Front Pharmacol., 9, 472. https://doi.org/10.3389/fphar.2018.00472
Published
2023-09-01
How to Cite
El Hachimi, F. E., & Le, K. L. (2023). Curcuma Longa Therapy for the Management and Treatment of Type 2 Diabetes: Quasi Experimental Pilot Study Design. European Journal of Science, Innovation and Technology, 3(4), 203-208. Retrieved from https://ejsit-journal.com/index.php/ejsit/article/view/252
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Copyright (c) 2023 Fouad E El Hachimi, Kim Lien Le
This work is licensed under a Creative Commons Attribution 4.0 International License.
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